목록연구노트/연구 실적 (3)
Biotechnology
Investigation of protein-protein interactions and hot spot region between PD-1 and PD-L1 by fragment molecular orbital method
원문 링크: https://www.nature.com/articles/s41598-019-53216-z 파일 링크: [Title] Investigation of protein-protein interactions and hot spot region between PD-1 and PD-L1 by fragment molecular orbital method [Abstract] Inhibitors to interfere protein-protein interactions (PPI) between programmed cell death 1 (PD-1) and programmed death ligand-1 (PD-L1) block evasion of cancers from immune surveillance. A..
Investigation of Hot Spot Region in XIAP Inhibitor Binding Site by Fragment Molecular Orbital Method
원문 링크: https://www.sciencedirect.com/science/article/pii/S2001037019302430?via%3Dihub Investigation of Hot Spot Region in XIAP Inhibitor Binding Site by Fragment Molecular Orbital Method X-linked inhibitor of apoptosis protein (XIAP) is an important regulator of cancer cell survival whose BIR3 domain (XIAP-BIR3) recognizes the Smac N-t… www.sciencedirect.com 파일 링크: [Title] Investigation of Hot S..
Application of the fragment molecular orbital method to discover novel natural products for prion disease
원문 링크: https://www.nature.com/articles/s41598-018-31080-7 파일 링크: [Title] Application of the fragment molecular orbital method to discover novel natural products for prion disease [Abstract] Conformational conversion of the normal cellular isoform of the prion protein PrPC into an infectious isoform PrPSc causes pathogenesis in prion diseases. To date, numerous antiprion compounds have been devel..